While developing a web site on my development service provided by Dreamhost, I found that I would occasionally (and randomly) run into the following error:
General error: 1615 Prepared statement needs to be re-prepared
I began searching for a solution thinking it might be something with the Laravel framework. Then I found this page about a MySQL bug.
Ultimately it appears that the best solution is to force the table cache to renew in mysql (more information about mysql repreperation), but if that is not an option, you can try forcing the table optimization or defragmentation for the table causing the issue.
This is understandably a work-around which is not idea for a production server. In the case of a production server, you can try modifying any of the following database settings:
table_open_cache 128=>16384 table_definition_cache 1024=>16384 tmp_table_size 32M=>64M join_buffer_size 256k=>512k
If you have any more information on this issue, please post a comment below!